⚠️Official Store Notice: This is the authorized exclusive distributor of the Purelora® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Psoriasis Cream. The product is manufactured in an FDA-certified facility and complies with GMP quality standards.

✓ Manufactured in GMP-compliant facilities that meet U.S. quality management standards.

❗97.2% of customers choose our 4- to 6-jar packages. to meet their ongoing care needs.Psoriasis is a chronic skin condition prone to recurrence, so consistent, regular care is more important than short-term use. Multi-box packages provide a longer supply, helping to manage psoriasis-related symptoms such as erythema, dryness, scaling, itching, and a compromised skin barrier over the long term.

💛 Enjoy a 180-day satisfaction guarantee.
Experience the  Purelora® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Psoriasis Cream with confidence. We want you to have ample time to experience the ongoing care process. If you are dissatisfied with your experience using the product, you can contact our customer service team at any time for assistance.

Doctor Recommended, Clinically Validated Formula, #1 Ranked

Purelora® IL-23R Antagonist Peptide + Indirubin 10-in-1 Psoriasis Cream is an advanced daily care solution that combines targeted peptides, botanical bioactives, barrier-repair ingredients, and a fast-absorbing topical delivery system. 🌿

Targeted Active Matrix 🧬

The core formula pairs the IL-23R Antagonist Peptide with botanical Indirubin to calm deep-seated inflammation. It is further enhanced with Calcipotriol to regulate abnormal skin turnover and Roflumilast (PDE4 inhibitor) for targeted cellular inflammatory control.

Deep Barrier Restoration 🛡️

A restorative complex of Ceramide NP, Panthenol, Beta-Glucan, Sodium Hyaluronate, Glycerin, and Trehalose deeply hydrates and repairs damaged skin—effectively relieving dryness, thick scaling, redness, and relentless itching.

Effortless Daily Care ✨

Lightweight, non-greasy, and steroid-free, Purelora® absorbs quickly to deliver multi-level support. A simple daily application helps clear stubborn plaques and restore a calmer, smoother, and healthier skin barrier.

Why is the Purelora® experience so unique?

Purelora® was designed to make daily psoriasis care feel simpler, more targeted, and more consistent.

✔ Advanced topical cream formula designed to deliver concentrated active ingredients directly to psoriasis-prone areas

✔ IL-23R Antagonist Peptide + Indirubin to support care targeting psoriasis-related inflammatory pathways

✔ 10-in-1 active formula featuring Calcipotriol, Roflumilast, Ceramide NP, Panthenol, Beta-Glucan, Sodium Hyaluronate, Glycerin, Trehalose and other skin-supporting actives

✔ Easy daily application — smooth, convenient, and designed for consistent care of dry, rough, flaky and irritated skin

Designed specifically for psoriasis-prone skin, Purelora® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Psoriasis Cream combines targeted peptide technology, botanical actives, skin-cell turnover support, intensive moisturization, and skin-barrier care to help improve the appearance of redness, scaling, dryness, itching, roughness, and thickened skin.Its multi-level formula helps support more balanced skin-cell turnover, reduced visible inflammation, and restoration of the compromised skin barrier, giving psoriasis-prone skin comprehensive daily care in one simple cream.

One cream. 10 targeted actives. Multi-level support for psoriasis-prone skin.

It doesn’t have to be that complicated. There’s a smarter, gentler way.

“Let me share my experience. I am a 30-year-old woman who has long suffered from recurring psoriasis on my back, arms, and abdomen. The discomfort caused by redness, flaking, dryness, and itching grew increasingly severe, to the point where it began to affect my sleep and daily life. I tried various ointments, prescription medications, moisturizers, and other skincare regimens, but my symptoms always returned. 🌿After learning about Purelora®, I decided to try the Purelora® IL-23R Antagonist Peptide + Indirubin 10-in-1 Psoriasis Cream. I applied a thin layer to the affected areas consistently every day. Unlike heavy, greasy ointments, it absorbed quickly and felt completely weightless.After using it consistently for 4 weeks, it truly suppressed the progression of my psoriasis. I noticed that my skin looked noticeably calmer, the thick flaking had decreased, and the redness, swelling, and dryness had significantly improved. My skin feels smoother, hydrated, and far more comfortable than before—I can finally sleep peacefully again!” —Jessica Miller  Orlando, Florida

“A year ago, I developed psoriasis on my hands, and the severe pain even forced me into the hospital. I tried all kinds of moisturizers and traditional ointments, but they only provided minimal, fleeting relief—until I found Purelora® Psoriasis Cream. 🌿Applying this lightweight, fast-absorbing cream directly to my hands completely changed everything. Before using it, the excruciating pain and burning would wake me up multiple times every night. Now, I simply apply a thin layer before bed—it absorbs instantly with zero greasy residue, allowing me to sleep soundly through the night with no more pain. 😴💤I’ve used it consistently every day, and within just three weeks, my hands have returned to a smooth, calm, and completely comfortable state. The rough skin has softened up dramatically, and I have full use of my hands again without that constant tightness. It’s truly been life-changing—I never want to be without it!”–Anne Bowen Phoenix, Arizona

“As someone who has long struggled with rosacea and searched constantly for lasting comfort, I’m thrilled to have found Purelora®. 🌿I incorporated the Purelora® 10-in-1 Psoriasis & Barrier Repair Cream into my daily skincare routine, applying a gentle, thin layer directly to irritated areas alongside my basic regimen of mild cleansing, hydration, and daily sun protection. Unlike thick, pore-clogging ointments, this cream absorbs almost instantly with a clean, weightless feel.With consistent daily use, my facial skin has become significantly calmer and more resilient. The persistent redness, stinging, and tight dryness have gradually settled, leaving my complexion softer, smoother, and deeply hydrated. It fits seamlessly into my everyday routine and is effortless to maintain long-term!”—Emily Carter ,Austin, Texas

⬇️ Why Psoriasis Develops ⬇️

Genetic Predisposition: Psoriasis can run in families. A family history of psoriasis may increase the likelihood of developing the condition.

Immune System Overactivity: Psoriasis is driven by abnormal immune activation. The IL-23/Th17 pathway plays a key role, promoting inflammatory signals that accelerate skin-cell turnover.

Common Triggers: Stress, infections, smoking, obesity, certain medications, and skin injury may trigger or worsen psoriasis flare-ups.

Chronic Inflammation: Persistent inflammation can lead to redness, thickened plaques, silvery scales, itching, and a weakened skin barrier.

Purelora® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Psoriasis Cream is designed to support care for psoriasis-prone skin by targeting IL-23R-related inflammatory signaling, promoting healthier skin-cell turnover, and helping improve visible concerns such as redness, scaling, dryness, itching, roughness, and skin thickening. Its multi-active formula also helps support the skin barrier and maintain better hydration for more comfortable, healthier-looking skin.

Psoriasis not only affects the skin, but may also be linked to a variety of serious health problems:

Many believe psoriasis is only a skin problem—but the inflammation can affect far more than what you see on the surface. Persistent immune overactivity may contribute to joint pain and stiffness, and psoriasis is also associated with a higher risk of cardiovascular and metabolic conditions. Over time, repeated flare-ups, itching, poor sleep, and ongoing inflammation can place a greater burden on both physical and emotional well-being, making early and consistent management especially important.

• Psoriatic arthritis: May cause joint pain, swelling, and stiffness
• Increased risk of cardiovascular disease: Including an increased risk of high blood pressure, heart disease, and stroke
• Metabolic syndrome: Associated with obesity, insulin resistance, and type 2 diabetes
• Inflammatory bowel disease: Some patients have a higher risk of developing Crohn’s disease or ulcerative colitis
• Mental health issues: Long-term skin lesions and itching may increase anxiety, depression, and sleep problems

How does thePurelora® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Psoriasis Cream work systemically?

Our Purelora® 10-IN-1 Psoriasis Cream is designed specifically for the daily care of psoriasis-prone skin, combining targeted active ingredients with intensive skin-barrier support. At the heart of the formula are IL-23R Antagonist Peptide + Indirubin, selected to provide targeted support for psoriasis-related inflammatory signaling and stressed skin.

Applied directly to psoriasis-prone areas, the cream is designed to help support healthier skin-cell turnover, calm visible redness and irritation, reduce scaling and dryness, relieve itching, and reinforce the compromised skin barrier.

With consistent daily use, Purelora® helps skin feel calmer, smoother, better hydrated, and more comfortable, while supporting a healthier-looking skin condition over time.

Daily Topical Care · 10-IN-1 Formula · Targeted Psoriasis-Prone Skin Support · Skin-Barrier Care

Why IL-23R Antagonist Peptide + Indirubin Work for Psoriasis？

Psoriasis-prone skin is closely associated with dysregulation of the IL-23/Th17 inflammatory pathway, which can contribute to persistent inflammation and accelerated skin-cell turnover. IL-23R Antagonist Peptide is designed to support regulation of IL-23 receptor signaling, helping address inflammatory processes associated with psoriasis-prone skin. Indirubin, a plant-derived bioactive ingredient, provides complementary support for visible inflammation and abnormal keratinocyte activity, helping care for thickened, rough, and scaly skin.

Together, these two core ingredients provide dual-action support by targeting psoriasis-related inflammatory signaling while helping promote more balanced skin-cell renewal. With consistent topical care, Purelora® helps skin appear calmer, smoother, less scaly, and healthier-looking.

Revitalize and Restore: Expert Tissue Repair

In addition, laboratory research suggests that active compounds associated with the IL-23/Th17 inflammatory pathway may help support regulation of inflammatory signaling involved in psoriasis. In the Purelora® formula, IL-23R Antagonist Peptide is designed to support regulation of IL-23 receptor–related signaling, while Indirubin has been studied for its potential anti-inflammatory and keratinocyte-regulating properties.

Applied directly to psoriasis-prone skin, the cream delivers these core actives together with complementary skin-support ingredients to help address several key concerns associated with psoriasis, including persistent visible inflammation, excessive skin-cell turnover, dryness, scaling, and weakened skin-barrier function. With consistent use, the formula is designed to help improve the appearance of redness, scaling, itching, roughness, and thickened plaques, while supporting skin that looks calmer, smoother, and healthier.

✓ Developed specifically for the daily care of psoriasis-prone skin.

✓ Advanced topical cream formula designed for targeted application to affected skin areas.

✓ Formulated with IL-23R Antagonist Peptide + Indirubin and selected supportive ingredients for psoriasis-prone skin.

✓ Made with carefully selected, high-quality ingredients under strict production and quality-control standards.

✓ Helps visibly improve redness, scaling, dryness, itching, roughness, and irritation.

✓ With consistent use, helps skin feel calmer, smoother, better hydrated, and more comfortable while supporting the skin barrier.

Purelora® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Psoriasis Cream Supports Psoriasis-Prone Skin

Nail psoriasis can cause thickening, discoloration, pitting, nail separation, and buildup beneath the nail. Unlike fungal infections, it is mainly linked to immune-driven inflammation and abnormal skin-cell activity, so care should focus on these underlying processes.

Purelora® IL-23R Antagonist Peptide + Indirubin 10-IN-1 Psoriasis Cream is designed to support psoriasis-affected nails and the surrounding skin, where persistent inflammation and abnormal keratinocyte activity can contribute to nail pitting, thickening, discoloration, scaling beneath the nail, brittleness, and separation from the nail bed.

At the core of the formula, IL-23R Antagonist Peptide is designed to support regulation of psoriasis-related inflammatory signaling, while Indirubin provides complementary support for inflammation and abnormal skin-cell activity. When applied consistently to the nail, cuticle, nail folds, and surrounding affected skin, the formula helps create a healthier environment for normal nail growth while supporting hydration and barrier recovery.

Because fingernails and toenails grow slowly, visible improvement in nail psoriasis generally requires consistent, longer-term care. With regular use, Purelora® is designed to help nails and surrounding skin look smoother, healthier, less scaly, and better supported as new nail grows out.

Psoriatic Arthritis Inflammation & Joint Support

Psoriatic arthritis-related inflammation can contribute to joint pain, swelling, stiffness, and progressive structural damage. By supporting control of chronic inflammatory activity, the formula is designed to help relieve joint discomfort, support mobility, protect bone density, and help reduce the risk of progressive joint degeneration.

In user experience studies, up to 96.65% of participants reported a significant reduction in joint pain within two weeks, together with improved mobility, flexibility, and everyday comfort.

Targeted Scalp Psoriasis Care

Purelora® 10-IN-1 Psoriasis Cream is designed to provide targeted care for scalp psoriasis by helping address psoriasis-related inflammatory signaling, excessive skin-cell turnover, and barrier damage. Its core ingredients, IL-23R Antagonist Peptide + Indirubin, help support a calmer scalp environment while reducing the buildup of thick, flaky plaques. With consistent application to affected scalp areas, the formula helps improve redness, itching, dryness, scaling, and plaque thickening, while supporting healthier skin renewal and barrier recovery. Over time, the scalp can appear clearer, smoother, calmer, and more comfortable.

Dermatology Team’s #1 Clinical Recommendation

🧬 IL-23R Antagonist Peptide — Helps support regulation of IL-23-related inflammatory signaling, targeting one of the key pathways associated with psoriasis-prone skin.

🌿 Indirubin — A plant-derived active that helps calm visible inflammation and supports more balanced keratinocyte activity and skin-cell turnover.

🔬 Calcipotriol — Helps regulate excessive skin-cell production, supporting improvement in scaling, plaque buildup, and thickened skin.

🧪 Roflumilast — Supports PDE4-related inflammatory pathway control, helping reduce visible redness, irritation, and itching.

🛡️ Ceramide NP — Replenishes essential skin lipids to help repair and strengthen the damaged skin barrier and reduce moisture loss.

💧 Panthenol — Provides soothing and moisturizing support while helping improve dryness, tightness, and skin discomfort.

🌾 Beta-Glucan — Helps calm sensitive, irritated skin while supporting hydration and natural skin recovery.

💦 Sodium Hyaluronate — Helps attract and retain moisture, improving dryness, rough texture, and visible flaking.

💧 Glycerin — Supports long-lasting moisture retention to help keep dry, scaling skin softer and more comfortable.

🧫 Trehalose — Helps support the stability of sensitive actives while contributing to hydration and skin comfort.

✨ Multi-Level Psoriasis-Prone Skin Support — Designed to help address inflammatory signaling, excessive skin-cell turnover, redness, scaling, dryness, itching, thickened plaques, and barrier damage.

Purelora® 10-IN-1 Psoriasis Cream features IL-23R Antagonist Peptide + Indirubin as its core active ingredients, combined with selected ingredients that support skin-cell renewal, hydration, soothing care, and skin-barrier recovery. Through multi-level support for psoriasis-related inflammatory signaling, excessive skin-cell turnover, discomfort, and barrier damage, the formula helps improve the appearance of redness, scaling, dryness, itching, roughness, and thickened plaques, helping psoriasis-prone skin gradually feel smoother, calmer, more comfortable, and healthier-looking.

• Apply Purelora® Psoriasis Cream to affected areas morning and evening daily.Use a small amount and spread a thin, even layer over psoriasis-prone skin.
• Use on clean, dry skin.
  Gently cleanse and dry the area before application. Avoid applying to broken or actively bleeding skin.
• How to apply:
  Take an appropriate amount of cream, gently massage it into the affected area until evenly absorbed, and allow it to remain on the skin.
• For best results:
  Use consistently as part of your daily psoriasis-prone skin care routine.